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59(8):4446-52
2Na/c5-1(3(7)8)2(6)4(9)10
18(27)21-13-6-4-3-5-12(13)17(25)26)9-15-22-16(23-28-15)14-8-7-11(24)10-20-14/h7-8
Formula: C19H23NO2
InChiKey: INBGSXNNRGWLJU-ZHHJOTBYSA-N
APG-1387 l D6 Nitrate 59(8):4446-52APG 1387, a bivalent SMAC mimetic and an IAP antagonist, blocks the activity of IAPs family proteins (XIAP, cIAP 1, cIAP 2, and ML IAP). APG 1387 induces degradation of cIAP 1 and XIAP proteins, as well as caspase 3 activation and PARP cleavage, which leads to apoptosis. APG 1387 can be used for the research of hepatocellular carcinoma, ovarian cancer, and nasopharyngeal carcinoma. Product information CAS Number: 1570231 89 8 Molecular Weight: 1157.
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